Particle therapy device and method for setting dose calibration factor

ABSTRACT

An irradiation apparatus radiates a particle beam after forming the beam for plural layers. A dose monitor measures a dose in real time. A dose evaluation unit evaluates an irradiation dose for each layer on the basis of a value measured by the dose monitor and a dose calibration factor set for each layer. An irradiation control section performs radiation control for each layer on the basis of an evaluation result of the dose evaluation unit. An interpolation value generation unit uses actual-measurement dose-calibration factors obtained by radiating a particle beam to a simulated phantom provided with a calibration dosimeter, to generate an interpolation estimation value of the dose calibration factor. For each layer subject to the interpolation value, and based on an irradiation condition of that layer, the interpolation value generation unit performs weighting on each of the actual-measurement dose-calibration factors.

TECHNICAL FIELD

The present invention relates to a particle therapy device for treatinga cancer or the like, by radiating a particle beam thereto, and inparticular, to a particle therapy device that employs a layer-stackingconformal irradiation method or a scanning irradiation method, as wellas to a method for setting a dose calibration factor.

BACKGROUND ART

As an irradiation method employed in a particle therapy device, there isknown: a layer-stacking conformal irradiation method in which anirradiation target is virtually partitioned into a plurality of layersin order of depth from the body surface and irradiation is performed forevery layer; and a scanning irradiation method. In employing eitherirradiation method, it is required to precisely recognize a dose duringirradiation in order to perform irradiation in line with a target doseplanned by a treatment plan device; however, it is impossible to place(implant) a dosimeter in a body as the irradiation target. As a result,generally, the dose (actual dose) in the irradiation target is estimatedbased on a measurement value of a dose monitor placed upstream of thebody surface in the traveling direction of the particle beam.

However, since the particle beam is not a parallel beam, but a fan beamor cone beam having a spread, variations in dose due to positionaldifferences in the body within a diseased site are not reflected in themeasurement value by the dose monitor, so that it is difficult toconvert the value simply into an actual dose.

In this respect, there is disclosed a particle therapy device thatperforms calibration using a dose calibration factor that has beenmeasured for every irradiation condition for treatment in considerationof influences not only by an atmospheric temperature and an atmosphericpressure but also a mechanical characteristic, on a relationship betweenthe actual dose and the measurement value by the dose monitor (forexample, see, Patent Document 1). Furthermore, there is also disclosed aparticle therapy device that calculates a dose calibration factor forevery layer in a layer-stacking conformal irradiation method or ascanning irradiation method (for example, see, Patent Document 2).

CITATION LIST Patent Document

-   Patent Document 1: Japanese Patent Application Laid-open    No.2008-245716 (Paragraphs 0009 to 0025, FIG. 1 to FIG.4)-   Patent Document 2: Japanese Patent Application Laid-open    No.2011-5276 (Paragraphs 0025 to 0039, FIG. 7 to FIG. 9)

SUMMARY OF THE INVENTION Problems to be Solved by the Invention

In the case of calculating a dose calibration factor, assuming as if awater phantom is an irradiation target, it is general to use ameasurement value of a dosimeter (reference dosimeter) put into thewater phantom and a measurement value of a dose monitor at the time ofvarying energy of the beam to be radiated or a depth of the referencedosimeter. However, since the water phantom itself has a restriction insize, there is a limitation in calculating the dose calibration factorcorresponding to every layer using the water phantom. Specifically,there is a problem that it is unable to make actual measurement when thedepth (water-equivalent depth) for measurement is deeper than anallowable depth for measurement by the water phantom.

Moreover, even when every layer set in the irradiation target to beirradiated is in a range of the water-equivalent depth that is allowablefor measurement by the water phantom, the pitch in water-equivalentdepth of each layer is small to fall in an order from little less than 1mm to several mm. Thus, assuming that the thickness of the irradiationtarget is, for example, 75 mm, it is necessary to perform actualmeasurements for as many as from about 30 to 100 times, and thus, thereis also a problem of taking a lot of trouble and time.

The present invention has been made to solve the problems as describedabove, and an object thereof is to provide a particle therapy device anda calibration method of an irradiation dose by which a highly accurateirradiation in line with a treatment plan is achieved.

Means for Solving the Problems

The particle therapy device of the invention is a particle therapydevice in which an irradiation target is partitioned into a plurality oflayers in order of depth from a body surface, and irradiation isperformed while an irradiation dose is controlled for each of thelayers, which is characterized by comprising: an irradiation apparatusthat radiates a particle beam supplied from an accelerator, afterforming the beam for said each of the layers; a dose monitor that isplaced in the irradiation apparatus and measures a dose in real time; adose evaluation unit that evaluates the irradiation dose for said eachof the layers on the basis of a dose that is calculated using ameasurement value measured by the dose monitor and using a dosecalibration factor set for said each of the layers, and a dosedetermined by a treatment plan; an irradiation control device thatcontrols a irradiation amount to said each of the layers on the basis ofan evaluation result of the dose evaluation unit; and an interpolationvalue generation unit that uses actual-measurement dose-calibrationfactors each obtained by radiating a particle beam to a simulatedphantom provided with a calibration dosimeter, to thereby generate aninterpolation value or an estimation value of the dose calibrationfactor for at least one of the layers for which the actual-measurementdose-calibration factor is not obtained; wherein, for each layer subjectto the interpolation value or the calibration value, based on anirradiation condition of that layer, the interpolation value generationunit performs weighting on each of the actual-measurementdose-calibration factors.

Further, the method for setting a dose calibration factor of theinvention is a method for setting a dose calibration factor that is usedin a particle beam therapy in which an irradiation target is partitionedinto a plurality of layers in order of depth from a body surface andirradiation is performed while an irradiation dose is controlled foreach of the layers, and that is for calculating a dose in theirradiation target using a measurement value of a dose monitor placed inan irradiation apparatus; which is characterized by comprising: a stepof radiating a particle beam to a simulated phantom provided with acalibration dosimeter to thereby obtain actual-measurementdose-calibration factors each using a depth of the calibration dosimeterin the simulated phantom as a parameter, on the basis of the measurementvalue of the dose monitor and a measurement value of the calibrationdosimeter; and an interpolation value generation step of establishing amathematical function of the dose calibration factor having the depth asa variable, on the basis of the actual-measurement dose-calibrationfactors, to thereby generate an interpolation value or an estimationvalue of the dose calibration factor corresponding to a layer for whichthe actual-measurement dose-calibration factor is not obtained; wherein,in the interpolation value generation step, for the layer subject to theinterpolation value or the calibration value, based on an irradiationcondition corresponding to that layer, weighting is performed on each ofthe actual-measurement dose-calibration factors.

EFFECT OF THE INVENTION

According to the particle therapy device and the method for setting adose calibration factor of the invention, since it is possible toprecisely calibrate a dose even for a layer for which no actual dose hasbeen measured, a highly accurate irradiation in line with the treatmentplan can be achieved.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram for illustrating a configuration of a particletherapy device and a method for setting a dose calibration factor,according to Embodiment 1 of the invention.

FIG. 2 is a diagram schematically showing apparatuses/instrumentsconstituting the particle therapy device according to Embodiment 1 ofthe invention.

FIG. 3 is a block diagram for illustrating a configuration of a doseevaluation unit of the particle therapy device and the method forsetting a dose calibration factor, according to Embodiment 1 of theinvention.

FIG. 4 is a diagram schematically showing an apparatus configuration atthe time of performing a dose calibration in the particle therapy deviceaccording to Embodiment 1 of the invention.

FIG. 5 is a graph representing a relationship among water-equivalentdepths of respective layers, actually-measured dose calibration factorsand interpolated dose calibration factors, with respect to the particletherapy device according to Embodiment 1 of the invention.

FIG. 6 is a graph representing a relationship between water-equivalentdepths of respective layers with different irradiation conditions andactually-measured dose calibration factors, with respect to a particletherapy device according to Embodiment 2 of the invention.

MODES FOR CARRYING OUT THE INVENTION Embodiment 1

Hereinafter, description will be made about a configuration of aparticle therapy device according to Embodiment 1 of the invention. FIG.1 to FIG. 5 are for illustrating the particle therapy device and amethod for setting a dose calibration factor, according to Embodiment ofthe invention, in which FIG. 1 is an overall functional-block diagramfor illustrating a configuration of the particle therapy device and themethod for setting a dose calibration factor; FIG. 2 is an overalldiagram for schematically illustrating an apparatus configuration at thetime of performing a particle beam therapy; FIG. 3 is a functional blockdiagram of a dose evaluation unit, for illustrating a configuration ofthe particle therapy device and the method for setting a dosecalibration factor; FIG. 4 is a diagram for illustrating an apparatusconfiguration at the time of performing a dose calibration in acalibration stage; and FIG. 5 is a graph for calculating a dosecalibration factor for making an irradiation dose, in which representedis a relationship among water-equivalent depths of respective layers,actually-measured dose calibration factors and interpolated dosecalibration factors.

The particle therapy device and the method for setting a dosecalibration factor according to Embodiment 1 of the invention arecharacterized by a configuration for generating an interpolation valueor an estimation value for precisely evaluating an irradiation dose in alayer for which no actual dose has been measured. However, prior to thedescription of that configuration, description will be made about aconfiguration of the particle therapy device for virtually partitioningan irradiation target into a plurality of layers in order of depth froma body surface to thereby perform irradiation for every layer, and anapparatus configuration at the time of obtaining a dose calibrationfactor. Note that, hereinafter, for simplifying the description, theinterpolation value and the estimation value are referred collectivelyto as an interpolation value.

As shown in FIG. 2, a particle therapy device 1 according to Embodiment1 of the invention includes: as a supply source of a particle beam (beamsource), an accelerator 30 which is a synchrotron; an irradiationapparatus 10 that radiates the particle beam supplied from theaccelerator 30 after forming the beam according to a diseased site(irradiation target); and a particle beam transport section 20 thatconnects the accelerator 30 with a plurality of irradiation apparatuses10 (including one not shown in the figure) and transports the particlebeam emitted from the accelerator 30 to the selected irradiationapparatus 10.

The accelerator 30 includes a vacuum duct 31 that provides a trajectorychannel for causing charged particles to go around therethrough; aninjection device 32 for injecting the charged particles supplied from apre-accelerator 38 into the vacuum duct 31; bending magnets 33 fordeflecting the trajectory of the charged particles so that the chargedparticles circulate along the round trajectory in the vacuum duct 31; aconvergence electromagnet 34 that causes the charged particles on theround trajectory to converge so as not to diverge; a high-frequencyacceleration cavity 35 that applies to the circulating chargedparticles, a high frequency voltage synchronous with the particles tothereby accelerate them; an emission device 36 for taking out from theround trajectory the charged particles accelerated in the roundtrajectory, as a particle beam having a predetermined energy, so as toemit it to the particle beam transport section 20; and a six-poleelectromagnet 37 that excites resonance in the round trajectory foremitting the particle beam from the emission device 36. Here, thecharged particles in the round trajectory are accelerated by a highfrequency electric field up to approx.60% to 80% of the light velocitywhile being bent by the magnets, and emitted to the particle beamtransport section 20.

The particle beam transport section 20 is referred to as HEBT (HighEnergy Beam Transport) system, and includes a vacuum duct that providesa transport channel of the particle beam; a switching electromagnet forswitching the trajectory of the particle beam; and a bending magnet fordeflecting the particle beam by a predetermined angle. Note that, in thefigure, illustration is omitted about portions in the particle beamtransport section 20 other than vacuum-duct portions connected to aconnection part to the accelerator 30 and connected to the irradiationapparatus 10.

The irradiation apparatus 10 is placed in each of unshown treatmentchambers for applying a particle beam therapy to a patient K, and servesto radiate the particle beam supplied from the particle beam transportsection 20 to the diseased site after forming the beam into anirradiation field matched to the size and depth of the irradiationtarget. However, the particle beam supplied to the irradiation apparatus10 is a so-called pencil-like narrow beam. For this reason, theirradiation apparatus 10 is provided with a lateral-directionirradiation-field forming unit 11 for controlling, in the irradiationfield of the particle beam, a shape in a lateral direction (namely, in aplane perpendicular to a beam traveling direction), a depth-directionirradiation-field forming unit 13 for controlling in that field a shapein a depth direction (namely, in the beam traveling direction), and adose monitor 12 for monitoring (counting) the particle beam passing agiven region in real time to thereby output a measurement value C_(i) inorder to evaluate a dose radiated to the diseased site. Further, in thetreatment chamber, a treatment table 41, etc. for positioning andfastening the patient K under radiation, are provided with reference toan isocenter IC.

In the depth-direction irradiation-field forming unit 13, there areincluded, for example, a ridge filter 14 for spreading the width of theBragg peak, a range shifter 15 for changing the energy (range) of theparticle beam, and the like. In the lateral-direction irradiation-fieldforming unit 11, there are included, for example, an unshown scanningelectromagnet for deflecting the particle beam in a directionperpendicular to the beam traveling direction, and the like. There arecases where the irradiation field is subjected to forming directly bythe scanning electromagnet and where it is once enlarged, for example,into a circular shape by the scanning electromagnet and then subjectedto forming using a limiter such as a multileaf collimator or the like.

When the therapy is performed using such a particle therapy device 1, itis necessary to control its respective parts in their cooperativemanner. Thus, in terms of control, the particle therapy device 1 isrepresented as being configured with a treatment plan section 50, anirradiation control section 60, the accelerator 30, the particle beamtransport section 20, the irradiation apparatus 10, a position controlsection 40, and the like, as shown in FIG. 1.

The irradiation apparatus 10 has, as described above, a function forforming a proper irradiation field at the time of radiating the particlebeam to the patient, and the treatment plan section 50 has a function ofdetermining parameters of the respective devices in the irradiationapparatus 10 as proper values, in order to radiate with an intended dosedistribution. The position control section 40 has functions of executingfastening of the patient using the treatment table 41, etc., positioningand confirmation of a target (referred to also as a target volume) andthe like. The irradiation control section 60 controls operations of theaccelerator 30, the particle beam transport section 20, the irradiationapparatus 10 and the position control section 40, on the basis of theinstructions from the treatment plan section 50. Note that, prior to thedescription of a detailed configuration (FIG. 3) of the irradiationcontrol section 60, a flow of the particle beam therapy will bedescribed.

Here, the particle beam therapy is described separately as three stages.The three stages are (i) treatment planning stage, (ii) calibrationstage, and (iii) irradiation treatment stage.

In the treatment planning stage (i), by the treatment plan section 50(or an external treatment plan device), a plan is made regarding 1: fromwhat angle, 2: with what irradiation field, and 3: with what dose, theradiation is to be applied to the diseased site of the patient that isthe irradiation target.

In the calibration stage (ii), as shown in FIG. 3, a dose calibrationfactor for converting a measurement value detected by the dose monitor12 into a dose given to the irradiation target, is calculated by a doseevaluation unit 70 established in the irradiation control section 60.Specifically, as shown in FIG. 4, as a simulated phantom that simulatesa human body, a calibration device 80 including a water phantom 81 isplaced at the position where the treatment table 41 is to be placed atthe time of treatment. In the water phantom 81 placed on a heightadjusting table 84, a calibration dosimeter 82 is placed that is to bepositioned by a dosimeter actuating device 83, at a positioncorresponding to each of the layers that are set in order of depth fromthe body surface of the irradiation target. Then, a beam for calibration(correction) is radiated to the water phantom 81. At that time, themeasurement value C_(i) to be outputted from the dose monitor 12permanently installed in the irradiation apparatus 10 and a physicaldose D_(i) to be outputted from the calibration dosimeter 82 areactually measured, so that a dose calibration factor α_(i) representedby the formula (1) is calculated for each layer (each depth of thecalibration dosimeter 82 from the water surface) by a calibration factorcalculation unit 77.

$\begin{matrix}\left\lbrack {{Equation}\mspace{14mu} 1} \right\rbrack & \; \\{{{\alpha_{i}\left( x_{i} \right)}:=\frac{D_{i}}{C_{i}}},\mspace{31mu} {i = 1},2,3,{\ldots \mspace{14mu} n}} & (1)\end{matrix}$

Here, a subscript i is an index indicative of an i-th layer, and thedose calibration factor α_(i) [Gy/Count] is calculated as a valueresulted from dividing the physical dose D_(i) [Gy] actually measuredwith the beam for calibration using the calibration dosimeter 82, by themeasurement value C_(i) [Count] measured by the dose monitor 12 at thattime. The calculated dose calibration factor α_(i) for each layer isstored, as in a look-up table using the water-equivalent depth xi [mmWEL] for each layer as a parameter, in a dose data processing unit 71.

In the particle therapy device or the method for setting a dosecalibration factor according to Embodiment 1, there resides a feature ina configuration for precisely calculating an interpolation value β_(i)[Gy/Count] that is an estimation value of the dose calibration factorwith respect to a layer corresponding to a region at the depth formeasurement that is deeper than the allowable depth for measurement bythe water phantom 81. What is meant specifically is to vary the weightof each of the dose calibration factor α_(i) depending thewater-equivalent depth x_(i) at the time of establishing a function(mathematical model) for the interpolation value β_(i) corresponding toa given water-equivalent depth x_(i), using the dose calibration factorα_(i) based on the actually measured data.

For simplifying description, firstly, an example will be shown about acase where, regardless of weighting, the function (mathematical model)is established by the polynomial equation represented by the formula(2), followed by calculating unknown coefficients of the polynomialequation using a least-square method.

β_(i) =k ₀ +k ₁ x _(i) +k ₂ x _(i) ²   (2)

It should be noted that k₀, k₁, k₂ are unknown coefficients, which are,when A and B are defined as in the following formula (D1), calculated asrepresented by the formula (3).

$\begin{matrix}\left\lbrack {{Equation}\mspace{14mu} 2} \right\rbrack & \; \\{A:={{\begin{bmatrix}1 & x_{1} & x_{1}^{2} \\1 & x_{2} & x_{2}^{2} \\\vdots & \vdots & \vdots \\1 & x_{n} & x_{n}^{2}\end{bmatrix}\mspace{31mu} B}:=\begin{bmatrix}\alpha_{1} \\\alpha_{2} \\\vdots \\\alpha_{n}\end{bmatrix}}} & \left( {D\; 1} \right) \\{\begin{bmatrix}k_{0} & k_{1} & k_{2}\end{bmatrix} = {{:X} = {\left( {A^{T}A} \right)^{- 1}A^{T}B}}} & (3)\end{matrix}$

Further note that the superscript T represents a transposed matrix.

Although the degree of the polynomial equation may be increased ordecreased as appropriate, the inventors have confirmed experimentallythat, when there is a consecutive relationship between a depth of thelayer and an irradiation dose, the dose calibration factor can beestimated sufficiently accurately if the polynomial equation of secondorder is used. However, focusing on the fact that there are many casesin the particle beam therapy where a non-consecutive relationship arisesbetween a depth of the layer and an irradiation dose, the inventorscause the weight of each dose calibration factor α_(i) to vary dependingon the water-equivalent depth x_(i), at the generation of theinterpolation value β_(i).

Thus, in the dose data processing unit 71, as shown in FIG. 3, there isprovided in an interpolation value generation unit 74, a weight settingunit 75 for setting a weight of each dose calibration factor α_(i) onthe basis of the water-equivalent depth x_(i) for the interpolationvalue β_(i). This causes an interpolation value calculation unit 76 tocalculate using the dose calibration factor α_(i), the interpolationvalue β_(i) by the function in which the weights set by the weightsetting unit 75 are reflected. More specifically, in consideration ofthe fact that, in many cases, a region corresponding to a distal-sidelayer mostly becomes deeper than a measurement depth allowable formeasurement by the water-phantom 81, thus making the actual measurementunable, each unknown coefficient of the function is calculated using aweighted least-square method in which distal-side data is heavilyweighted.

Namely, instead of the aforementioned combination of the formula (D1)and the formula (3), unknown coefficients k₀, k₁, k₂ are calculated bythe combination of the formula (D2) and the formula (4).

$\begin{matrix}\left\lbrack {{Equation}\mspace{14mu} 3} \right\rbrack & \; \\{A:={{\begin{bmatrix}1 & x_{1} & x_{1}^{2} \\1 & x_{2} & x_{2}^{2} \\\vdots & \vdots & \vdots \\1 & x_{n} & x_{n}^{2}\end{bmatrix}\mspace{31mu} B}:={{\begin{bmatrix}\alpha_{1} \\\alpha_{2} \\\vdots \\\alpha_{n}\end{bmatrix}\mspace{31mu} W}:=\begin{bmatrix}1 & \; & \; & \; & \; & 0 \\\; & \ddots & \; & \; & \; & \; \\\; & \; & 1 & \; & \; & \; \\\; & \; & \; & 2 & \; & \; \\\; & \; & \; & \; & 5 & \; \\0 & \; & \; & \; & \; & 10\end{bmatrix}}}} & \left( {D\; 2} \right) \\{\begin{bmatrix}k_{0} & k_{1} & k_{2}\end{bmatrix} = {{:X} = {\left( {A^{T}W^{T}{WA}} \right)^{- 1}A^{T}W^{T}{WB}}}} & (4)\end{matrix}$

In the formula (D2), W represents a diagonal matrix in which thenumerals arranged from upper left to lower right represent weights, thusrevealing that the weights (=2, 5, 10) set for lower-right deep layers(in the distal side) are made larger than the weight (=1) set forupper-left shallow layers (in the proximal side).

Each function (mathematical model) for estimating the dose calibrationfactor, including such a definition of W, is generated depending on thewater-equivalent depth x_(i) for calculating the interpolation valueβ_(i) and is being stored in the interpolation value generation unit 74.Then, in the weight setting unit 75, at the time of calculating theinterpolation value β_(i) for a layer deeper than the measurementallowable range, the function in which the weight is made larger at adistal side is used, whereas in the case within the measurementallowable range, the function in which weighting is made in a flattenedmanner or the function in which the weight is made large for a layernear to the depth of that range, is used. Namely, the weight settingunit 75 is configured so that it can appropriately select or modify thefunction depending on the water-equivalent depth x_(i) for calculatingβ_(i).

In the irradiation treatment stage (iii), during radiation to theirradiation target, the measurement value C_(i) outputted in real timeby the dose monitor 12 is outputted to a dose calculation unit 73 in thedose evaluation unit 70. The dose calculation unit calculates from themeasurement value C_(i), the irradiation dose given to the irradiationtarget (C_(i)×α_(i), or C_(i)×β_(i)) using the dose calibration factorα_(i) or the interpolation value β_(i) generated in the calibrationstage and corresponding to that layer, and outputs it to an evaluatingunit 72. At the evaluating unit 72, it is determined whether or not theoutputted dose has reached a target dose, and such an evaluation resultis outputted. This makes it possible to perform evaluation of dose inreal time, thus allowing an irradiation control to be performed based onthe evaluation result.

In order to accomplish irradiation consistent with the target dose, theirradiation control section 60, upon receiving the evaluation resultindicating that the dose in that layer has reached the target dose,controls operation of the irradiation apparatus 10 to stop irradiationat that layer followed by shifting toward the next layer.

It should be noted that, calculating the aforementioned interpolationvalue β_(i) corresponding to the water-equivalent depth x_(i) makes itpossible to precisely calculate the dose of the layer whose dosecalibration factor α_(i) is difficult to obtain based on an actualmeasurement value. Meanwhile, as represented by the polynomial equationof the formula (2), the interpolation value β_(i)is a value that variesconsecutively with respect to the depth direction, so that it isadvantageous, in terms of performing control, to use only theinterpolation value β_(i) even for the region with presence of the dosecalibration factor α_(i). However, in actual irradiation, as shown inFIG. 5, there is a case of exhibiting a property deviated from thepolynomial equation represented by the formula (2). Thus, in accordancewith the particle therapy device or the irradiation-dose calibrationmethod according to Embodiment 1, it is configured/designed so as to beable to select as to which one of the data of the dose calibrationfactor α_(i) and that of the interpolation value β_(i) is to be used,for the region with presence of the dose calibration factor α_(i).

A specific example thereof will be described using FIG. 5. In thefigure, the abscissa represents the water-equivalent depth x_(i) [mmWEL] (the depth of the calibration dosimeter 82 in the water phantom 81from the water surface) and the ordinate represents the dose calibrationfactor α_(i) or the interpolation value β_(i) [Gy/Count]. Note that, inthe figure, αa is dose calibration factor α_(i)-data selected for dosecalibration, αr is dose calibration factor α_(i)-data not selected fordose calibration, and a broken line is a curve representing the formula(2) and determined using the unknown coefficients that have beencalculated while performing weighting on the dose calibration factorα_(i). Further, βa is interpolation value β_(i)-data selected for dosecalibration and is interpolation value β_(i)-data not selected for dosecalibration.

In the figure, such a case is shown where, for the layer with presenceof the dose calibration factor α_(i), the interpolation value β_(i) isnot selected but the dose calibration factor α_(i) is selected. However,if the interpolation value β_(i) corresponds as a value to the datawithin a range of a variation σ of the dose calibration factor α_(i)(CP, in the figure), the interpolation value β_(i) may be selected inplace of the dose calibration factor α_(i).

Instead, the above selection may be done based on a signal from an inputscreen in the irradiation control section 60. Specifically, adoctor/technician who operates the particle therapy device 1, anoperator who operates the system based on an instruction by a doctor,etc. or the like, confirms which layer(s) (which order number layer(s)),the diseased site of the patient, as an irradiation target, correspondsto. For example, in the case where, as such corresponding layer(s),those with the indexes i=10 to 30 are corresponding thereto, when thedetermination whether to use the dose calibration factor α_(i) stored inthe lookup table or to use the interpolation value β_(i) based on thefunction, is done for each of the layers on the input screen in theirradiation control section 60, its result is outputted to the dose dataprocessing unit 71.

In either instance, when a calibration depth about the patient withrespect to a shot at a distal side is placed in a region Ro that isdeeper than the depth region Rm allowable for measurement by the waterphantom and thus not allowed at all for actual measurement, namely, whenthere is no corresponding dose calibration factor α_(i) in the lookuptable, this results in using the interpolation value β_(i),automatically.

Consequently, it becomes possible to perform dose evaluation ensuringboth smoothness in control and preciseness. Note that, in the aboveexample, description has been made about a case where the doseevaluation unit 70 is established in the irradiation control section 60and the calibration factor calculation unit 77, etc. are established inthe dose evaluation unit 70; however, its modification is of course bepossible as appropriate, so long as capable of exhibiting theperformance described above.

As described above, in accordance with the particle therapy deviceaccording to Embodiment 1, there is provided a particle therapy device 1in which an irradiation target is partitioned into a plurality of layersin order of depth from a body surface, and irradiation is performedwhile an irradiation dose is controlled for each of the layers,

said particle therapy device configured to include: the irradiationapparatus 10 that radiates a particle beam supplied from the accelerator30, after forming the beam for said each of the layers; the dose monitor12 that is placed in the irradiation apparatus 10 and measures a dose inreal time; the dose evaluation unit 70 that evaluates the irradiationdose for said each of the layers on the basis of a dose that iscalculated using the measurement value C_(i) measured by the dosemonitor 12 and using the dose calibration factor (α_(i), β_(i)) set forsaid each of the layers, and a dose determined by a treatment plan; anirradiation control device (the irradiation control section 60) thatcontrols a irradiation amount to said each of the layers on the basis ofan evaluation result of the dose evaluation unit 70; and theinterpolation value generation unit 74 that uses actual-measurementdose-calibration factors α_(i) each obtained by radiating a particlebeam to a simulated phantom (the water phantom 81) provided with thecalibration dosimeter 82, to thereby generate the interpolation valueβ_(i) of the dose calibration factor for at least one of the layers forwhich the actual-measurement dose-calibration factor α_(i) is notobtained;

wherein, at the time of generating the interpolation value β_(i) for thelayer whose depth x_(i) is deeper than a predetermined value (forexample, a measuring limit by the water phantom 81), the interpolationvalue generation unit 74 performs weighting so that a weight of theactual-measurement dose-calibration factor α_(i) at a deep layer amongthe actual-measurement dose-calibration factors α_(i) is larger than aweight of the actual-measurement dose-calibration factor α_(i) at ashallow layer there among. Thus, even for the layer whose depth x_(i) isdeeper than the predetermined value and which is thus not allowed formeasurement by the simulated phantom (water phantom 81), a preciseinterpolation value β_(i) can be obtained and thus the dose can becalibrated precisely, so that it is possible to achieve a highlyaccurate irradiation in line with the treatment plan.

Further, in accordance with the method for setting a dose calibrationfactor according to Embodiment 1, there is provided a method for settinga dose calibration factor (α_(i), β_(i)), that is used in a particlebeam therapy in which an irradiation target is partitioned into aplurality of layers in order of depth from a body surface andirradiation is performed while an irradiation dose is controlled foreach of the layers, and that is for calculating a dose in theirradiation target using a measurement value C_(i) of the dose monitor12 placed in the irradiation apparatus 10;

said method is designed to include: a step of radiating a particle beamto a simulated phantom (water phantom 81) provided with the calibrationdosimeter 82 to thereby obtain actual-measurement dose-calibrationfactors α_(i) each using a depth x_(i) of the calibration dosimeter 82in the simulated phantom (water phantom 81) as a parameter, on the basisof the measurement value C_(i) of the dose monitor 12 and themeasurement value (physical dose Di) of the calibration dosimeter 82;and an interpolation value generation step of establishing amathematical function (formula (2)) of the dose calibration factor α_(i)having a depth x_(i) as a variable, on the basis of theactual-measurement dose-calibration factors α_(i), to thereby generatethe interpolation value β_(i) of the dose calibration factorcorresponding to the layer for which the actual-measurementdose-calibration factor α_(i) is not obtained;

wherein, in the interpolation value generation step, at the time ofgenerating the interpolation value β_(i) for the layer whose depth x_(i)is deeper than a predetermined value (for example, a measuring limit bythe water phantom 81), weighting is performed so that a weight of theactual-measurement dose-calibration factor α_(i) at a deep layer amongthe actual-measurement dose-calibration factors α_(i) is larger than aweight of the actual-measurement dose-calibration factor α_(i) at ashallow layer there among. Thus, even for the layer for which no actualdose has been measured, the dose can be calibrated using a precisefactor for calibration of dose, so that it is possible to achieve ahighly accurate irradiation in line with the treatment plan.

Embodiment 2

In Embodiment 1, the description has been made about a case where, atthe calculation of the interpolation value β_(i), weighting is performedwith attention to the water-equivalent depth; however, in Embodiment 2,weighting is performed in consideration also of an irradiation conditionother than the water-equivalent depth. FIG. 6 is for illustrating aparticle therapy device or a method for setting a dose calibrationfactor according to Embodiment 2, and is a graph representingschematically a relationship between water-equivalent depths ofrespective layers with different irradiation conditions with respect tothe particle therapy device and actually-measured dose calibrationfactors. Note that, for the configuration related to the particletherapy device and its control, the figures used in Embodiment 1 willalso be used, and similar parts therein will be omitted fromdescription.

In Embodiment 2, focusing is taken to the fact that, when a variationoccurs in water-equivalent depth, a range of the particle beam (aposition of the Bragg peak) is adjusted for achieving irradiation atthat water-equivalent depth, so that a dose distribution varies. Factorsfor varying the dose distribution depending on the range of the radiatedparticle beam, include, <1> Fan Beam Effect or Cone Beam Effect, <2>Difference in Type (Thickness) of Range Shifter 15 in Use, and <3>Difference in Wobbler Radius (in the case of a layer-stacking conformalirradiation). In the followings, description will be made about them,respectively.

<1> Fan Beam Effect or Cone Beam Effect

As described previously, the irradiation apparats 10 serves to form thepencil-like narrow beam supplied from the accelerator 30 into thatmatched to a shape of the diseased site, so as to achieve the dosedistribution planned for treatment. Thus, the supplied beam is enlargedin x-y direction by a scatterer or a wobbler electromagnet (broad beammethod (including the case of a layer-stacking conformal irradiation))placed in the lateral-direction irradiation-field forming unit 11, orscanned in x-y direction by a scanning electromagnet (scanning method)placed therein.

Accordingly, the beam that will reach the irradiation target from theirradiation apparatus 10 is not parallel, and is radiated so that itpasses a region spread in a fan-like or cone-like manner by thescatterer/the wobbler electromagnet or the scanning electromagnet.Accordingly, this results in difference of the dose distribution (thismay be assumed to be a number of particles per unit area) due todifference in the range, even if the intensity of the originalpencil-like narrow beam is unchanged (the number of particles per unittime is unchanged). Thus, even when the measurement value C_(i)(corresponding to the number of particles) counted by the dose monitor12 placed in the irradiation apparatus 10 is unchanged, different rangesresult in different dose distributions given to the patient. This factis called a fan beam effect or a cone-beam effect.

<2> Effect Due to Difference in Type (Thickness) of Range Shifter in Use

As methods for changing the range of the particle beam, there are twomethods. The first one is a method for changing the kinetic energy ofthe particles accelerated in the accelerator 30-side. The second one isa method for causing the particle beam supplied with a given energy topass the range shifter 15 having a different thickness, to therebyadjust an amount of loss in the kinetic energy that the particles have.The method by using the accelerator 30 is suited to roughly adjust theenergy level, whereas the method by changing the type of the rangeshifter 15 is suited to finely adjust the energy level. In the actualapparatus, it is general to use these two methods together.

The range shifter 15 is placed, as the depth-direction irradiation-fieldforming unit 13, in the irradiation apparatus 10, and starts spreadingthe particle beam at the time it passes the range shifter 15. The degreeof this spreading depends largely on the thickness of the range shifter15, which also results in different dose distributions due to differencein the thickness of the range shifter 15. The degree of the spreadingparticularly largely changes at the difference between the case of notusing the range shifter 15 at all and the case of using the rangeshifter 15. In order to avoid this influence as much as possible, evenin the case of the target energy for which the range shifter 15 is notnecessary, it is also effective to nevertheless add a thin range shifter15 as a dummy.

<3> Difference in Wobbler Radius (in the case of a Broad Beam Method,such as a Layer-Stacking Conformal Irradiation)

As described previously, in the case of the broad beam method, in orderto achieve the dose distribution planned for treatment in conformitywith the shape of diseased site, the pencil-like narrow beam supplied tothe irradiation apparatus 10 is enlarged in x-y direction using awobbler electromagnet or the like. In more particular, the wobblerelectromagnet causes the pencil-like narrow beam to scan, for example,in a circular motion, and then, the particle beam is radiated so as topass the scatterer. This achieves mostly uniform dose distribution inthe enlarged irradiation field. The radius in the circular motion of thebeam is called “wobbler radius”.

Thereafter, the irradiation field is formed to be matched to the shapeof diseased site of the patient, in such a manner that its unnecessaryportion is blocked off by a collimator or the like. On this occasion, itis sufficient that the size of the irradiation field having such auniform dose distribution be large to such an extent capable of fullyenclosing the diseased site of the patient. Thus, in consideration ofthe utilization efficiency of the beam, it is allowed to intentionallychange the wobbler radius depending on the size of the diseased site (oreach layer) of the patient. This wobbler radius is also a factor bywhich the dose distribution varies.

Description will be made about how the above factors <1> to <3> wouldinfluence, citing a case of a layer-stacking conformal irradiation. Thediseased site of the patient, as an irradiation target, is partitionedinto some virtual slices (layers) in abeam-axis direction (depthdirection, z-direction). For simplicity's sake, numbers are given to theslices (1, 2, . . . n, from the distal side). Although it is notnecessary that this order (from the distal side) be always an order ofirradiation for the slices, the order of irradiation preformed from thedistal side is well adopted in medical scenes. In order to achieveradiation to each slice, the energy of the particle beam is adjusted asthe range (position of the Bragg peak) of the radiation beam. While theenergy of the particle beam is to be adjusted using the accelerator 30and the range shifter 15 together as described previously, on thisoccasion, a parameter of the accelerator 30 and the range shifter 15 tobe used are determined.

What dose calibration factor is used for each of the virtual slices atthe treatment, is determined through prior measurement (in thecalibration stage) using the water phantom 81. Here, for that dosecalibration factor, although it is conceivable to calculate theinterpolation value β_(i) as described in Embodiment 1 using thepolynomial model (formula (2)) that uses a water-equivalent depth as aparameter, a problem of non-consecutiveness arises in a dose-calibrationfactor characteristic curve, due to the irradiation method, such as theaforementioned energy adjusting method, etc. In the followings,description will be made using FIG. 6.

FIG. 6 is a graph schematically representing a relationship between thedose calibration factor α_(i) calculated in the calibration stage on thebasis of the actually measured result using the water phantom 81 and thewater-equivalent depth x_(i). In the figure, the abscissa represents thewater-equivalent depth x_(i) [mm WEL] (the depth of the calibrationdosimeter 82 in the water phantom 81 from the water surface) and theordinate represents a value resulted from dividing the dose [Gy]obtained by the calibration dosimeter 82 by the measurement value C_(i)[Count] of the dose monitor 12 placed in the irradiation apparatus 10.

Further, for simplicity's sake, here is assumed that the parameters ofthe energy of the particle beam emitted from the accelerator 30(accelerator's parameters) are of three types: A, B and C, and the typesof the thickness and material of the range shifter 15 (range-shifter'sparameters) are three types: a, b and c. The respective plots indicatethe measurement result, and from the left side (shallow in thewater-equivalent depth) to the right side (deep in the water-equivalentdepth), correspond to the data under conditions of Aa, Ab, Ac, Ba, Bb,Bc, Ca, Cb and Cc. With the characteristic curve of the dose calibrationfactor obtained in the case of such layer-dependent differentconditions, there is a problem that, when it is to be totallyapproximated by a single polynomial equation, non-consecutiveness hasarisen in its characteristic.

Here, if focusing only to the data (Aa, Ab, Ac) corresponding to theparameter A among the accelerator's parameters, non-consecutiveness doesnot arise in its characteristic, so that it is possible to achievemodeling precisely using a single polynomial equation. Further, iffocusing only to the data (Aa, Ba, Ca) corresponding to the parameter aamong the range-shifter's parameters, non-consecutiveness does not arisein its characteristic, so that it is also possible to achieve precisemodeling similarly using a single polynomial equation. Namely, when datais divided into groups depending on the accelerator's parameter or therange-shifter's parameter, followed by preparing to store a polynomialequation of the dose-calibration factor characteristic curvecorresponding to the group using the data of the same group, it ispossible to resolve the problem of the non-consecutiveness, to therebyobtain the interpolation value β_(i) with excellent accuracy.

Although the description has been made based on FIG. 6 about thegrouping by the accelerator's parameter and the grouping by therange-shifter's parameter, because a similar problem ofnon-consecutiveness arises due to a difference in wobbler radius(wobbler-radius parameter), a grouping by the wobbler-radius parameteris also usable of course.

Namely, according to an irradiation condition (parameter) of a layerthat requires the interpolation value β_(i), the weight setting unit 75described with FIG. 3 sets to zero the weights of dose calibrationfactors α_(i) for layers whose conditions are different to thatirradiation condition. This makes it possible to resolve the problem ofnon-consecutiveness to thereby obtain the interpolation value β_(i) withexcellent accuracy, so that a highly accurate irradiation in line withthe treatment plan can be achieved.

As described above, in accordance with the particle therapy deviceaccording to Embodiment 2, the interpolation value generation unit 74 isconfigured to perform weighting on each of the actual-measurementdose-calibration factors α_(i), for each layer subject to theinterpolation value β_(i), on the basis of commonality in any one or anycombination of the accelerator's parameter for adjusting the energy, therange-shifter's parameter and the wobbler radius parameter for adjustingthe size of the irradiation field, as irradiation conditions for saideach layer, in addition to the depth as described previously. Thus, evenfor the layer for which no actual dose has been measured, since the dosecan be calibrated precisely, it is possible to achieve a highly accurateirradiation in line with the treatment plan.

Further, in accordance with the method for setting a dose calibrationfactor according to Embodiment 2, in the interpolation value generationstep, it is designed to perform weighting on each of theactual-measurement dose-calibration factors α_(i), for each layersubject to the interpolation value β_(i), on the basis of commonality inany one or any combination of the accelerator's parameter for adjustingthe energy, the range-shifter's parameter and the wobbler radiusparameter for adjusting the size of the irradiation field, asirradiation conditions for said each layer, in addition to the depth asdescribed previously. Thus, even for the layer for which no actual dosehas been measured, since the dose can be calibrated using a precisefactor for calibration of dose, it is possible to achieve a highlyaccurate irradiation in line with the treatment plan.

Embodiment 3

In Embodiment 2, the description has been made about a case of usingonly the dose calibration factors of the layers whose conditions are thesame as that of a layer that wants to obtain the interpolation value.However, in practice, the region required for the polynomial model is aregion having a specified width that is “deeper than the depth allowablefor measurement by the water phantom”. Thus, in that region, aninfluence due to a plurality of parameters exists. Namely, in thatregion, an influence emerges due to “accelerator's parameter”,“range-shifter's parameter”, “wobbler radius parameter”, etc., in theiroverlapped manner. Thus, in the particle therapy device or the methodfor calibrating an irradiation dose according to Embodiment 3, ablack/white decision is not taken whether “to use/not to use” each dosecalibration factor as data for obtaining the interpolation value, butweighting is taken on the factor in view of a plurality of conditions.Note that, also in Embodiment 3, for the configuration related to theparticle therapy device and its control, the figures used in Embodiment1 will also be used, and similar parts therein will be omitted fromdescription.

For simplifying description, description will be made about a case whereweighting is performed when the irradiation conditions are narrowed totwo conditions of the accelerator's parameter and the wobbler radiusparameter.

Here, the layer (slice) that wants to obtain the interpolation valueα_(i) is assumed to be a deeper layer (distal side) than thewater-equivalent depth allowable for measurement by the water phantom81. As to the accelerator's parameter, as described with FIG. 6, thereare three conditions of A, B and C from the shallow side of thewater-equivalent depth toward the deep side thereof. Further, theaccelerator's parameter for deeper layers (distal side) than thewater-equivalent depth allowable for measurement is assumed to C.Accordingly, as a unit coefficient to be used at the time of setting theweight, 1.0 is set in the cases of a common condition of C; and withrespect to different conditions of B and A, 0.8 is set in thenearer-depth cases of B, and 0.5 is set in the farthest cases of A.

Meanwhile, as to the wobbler radius parameter, there are threeconditions of X mm, X+20 mm and X+40 mm from the small side of theradius toward the large side thereof. Further, the radius is assumed toX mm at the time of achieving irradiation of a distal-side layer thatwants to obtain the interpolation value β_(i). Accordingly, as a unitcoefficient to be used at the time of setting the weight, 1.0 is set inthe cases of a common condition of X mm; with respect to other twodifferent conditions, 0.4 is set in the cases of X+20 mm that is nearerto X, and 0.2 is set in the most different cases of X+40 mm.

When the unit coefficient for weighting is set for each type of therespective parameters in this manner, and when each actual-measurementdose-calibration factor α_(i) is multiplied by the unit coefficient foreach parameter according to the combination of irradiation conditions,it becomes possible to perform weighting as shown in Table 1.

TABLE 1 Examples of Combination in Condition and Weighting Accelerator'sParameter Condition C B A Wobbler X mm 1 0.8 0.5 Radius X + 20 mm 0.40.32 0.2 X + 40 mm 0.2 0.16 0.1

Note that, in order to perform the aforementioned calibration, forexample, the respective unit coefficients, etc., are stored in the dosedata processing unit 71, as well as the calibration factor calculationunit 77 is, at the time of calculating the dose calibration factorα_(i), caused to associate it with the data of the irradiation condition(s). Accordingly, in the weight setting unit 75, when the associateddata-based reflection is applied to the definition of W in the formula(D2), the weight of the dose calibration factor α_(i) can be adjustedaccording to the irradiation condition (s) of the layer that wants theinterpolation value β_(i). This makes it possible to obtain theinterpolation value β_(i) with excellent accuracy while taking intoconsideration the total characteristic in view of the problem ofnon-consecutiveness and the influence by the plurality of conditions, sothat a highly accurate irradiation in line with the treatment plan canbe achieved.

As described above, in accordance with the particle therapy deviceaccording to Embodiment 3, the interpolation value generation unit 74 isconfigured: to determine the unit coefficients for weighting, on thebasis of commonality about each of the depth, the accelerator'sparameter for adjusting the energy, the range-shifter's parameter andthe wobbler radius parameter for adjusting the size of the irradiationfield, as irradiation conditions; and to perform, for each layer subjectto the interpolation value β_(i), weighting on each of theactual-measurement calibration factors α_(i) according to a combinationof the respective parameters, using the value multiplied by each of theunit coefficients. Thus, a dose can be calibrated precisely even for thelayer for which no actual dose has been measured, so that it is possibleto achieve a highly accurate irradiation in line with the treatmentplan.

Further, in accordance with the method for setting a dose calibrationfactor according to Embodiment 3, in the interpolation value generationstep, it is designed: to determine the unit coefficients for weighting,on the basis of commonality about each of the depth, the accelerator'sparameter for adjusting the energy, the range-shifter's parameter andthe wobbler radius parameter for adjusting the size of the irradiationfield, as irradiation conditions; and to perform, for each layer subjectto the interpolation value β_(i), weighting on each of theactual-measurement calibration factors α_(i) according to a combinationof the respective parameters, using the value multiplied by each of theunit coefficients. Thus, a dose can be calibrated using a precise factorfor calibration of dose even for the layer for which no actual dose hasbeen measured, so that it is possible to achieve a highly accurateirradiation in line with the treatment plan.

As described above, in accordance with the particle therapy devicesaccording to the respective Embodiments 1 to 3, there is provided aparticle therapy device 1 in which an irradiation target is partitionedinto a plurality of layers in order of depth from a body surface, andirradiation is performed while an irradiation dose is controlled foreach of the layers,

said particle therapy device configured to include: the irradiationapparatus 10 that radiates a particle beam supplied from the accelerator30, after forming the beam for said each of the layers; the dose monitor12 that is placed in the irradiation apparatus 10 and measures a dose inreal time; the dose evaluation unit 70 that evaluates the irradiationdose for said each of the layers on the basis of a dose that iscalculated using the measurement value C_(i) measured by the dosemonitor 12 and using the dose calibration factor (α_(i), β_(i)) set forsaid each of the layers, and a dose determined by a treatment plan; anirradiation control device (the irradiation control section 60) thatcontrols a irradiation amount to said each of the layers on the basis ofan evaluation result of the dose evaluation unit 70; and theinterpolation value generation unit 74 that uses actual-measurementdose-calibration factors α_(i) each obtained by radiating a particlebeam to a simulated phantom (the water phantom 81) provided with thecalibration dosimeter 82, to thereby generate the interpolation valueβ_(i) of the dose calibration factor for at least one of the layers forwhich the actual-measurement dose-calibration factor α_(i) is notobtained;

wherein, for each layer subject to the interpolation value β_(i) andbased on an irradiation condition of that layer, the interpolation valuegeneration unit 74 performs weighting on each of the actual-measurementdose-calibration factors. Thus, a dose can be calibrated precisely evenfor the layer for which no actual dose has been measured, so that it ispossible to achieve a highly accurate irradiation in line with thetreatment plan.

Further, in accordance with the methods for setting a dose calibrationfactor according to the respective Embodiments 1 to 3, there is provideda method for setting a dose calibration factor (α_(i), β_(i)), that isused in a particle beam therapy in which an irradiation target ispartitioned into a plurality of layers in order of depth from a bodysurface and irradiation is performed while an irradiation dose iscontrolled for each of the layers, and that is for calculating a dose inthe irradiation target using a measurement value C_(i) of the dosemonitor 12 placed in the irradiation apparatus 10;

said method is designed to include: a step of radiating a particle beamto a simulated phantom (water phantom 81) provided with the calibrationdosimeter 82 to thereby obtain actual-measurement dose-calibrationfactors α_(i) each using a depth X_(i) of the calibration dosimeter 82in the simulated phantom (water phantom 81) as a parameter, on the basisof the measurement value C_(i) of the dose monitor 12 and themeasurement value (physical dose D_(i)) of the calibration dosimeter 82;and an interpolation value generation step of establishing amathematical function (formula (2)) of the dose calibration factor α_(i)having a depth x_(i) as a variable, on the basis of theactual-measurement dose-calibration factors α_(i), to thereby generatethe interpolation value β_(i) of the dose calibration factorcorresponding to the layer for which the actual-measurementdose-calibration factor α_(i) is not obtained;

wherein, in the interpolation value generation step, for the layersubject to the interpolation value β_(i) and based on an irradiationcondition corresponding to that layer, weighting is performed on each ofthe actual-measurement dose-calibration factors α_(i). Thus, even forthe layer for which no actual dose has been measured, the dose can becalibrated using a precise factor for calibration of dose, so that it ispossible to achieve a highly accurate irradiation in line with thetreatment plan.

DESCRIPTION OF REFERENCE NUMERALS and SIGNS

-   1: particle therapy device, 10: irradiation apparatus, 11:    lateral-direction irradiation-field forming unit, 12: dose monitor,    13: depth-direction irradiation-field forming unit, 14: ridge    filter, 15: range shifter, 20: particle beam transport section, 30:    accelerator, 40: position control section, 41: treatment table, 50:    treatment plan section, 60: irradiation control section, 70: dose    evaluation unit, 71: dose data processing unit, 72: evaluating unit,    73: dose calculation unit, 74: interpolation value generation unit,    75: weight setting unit, 76: interpolation value calculation unit,    77: calibration factor calculation unit, 80: calibration device, 81:    water phantom (simulated phantom), 82: calibration dosimeter, C_(i):    measurement value, D_(i): physical dose, IC: isocenter, K: patient,-   α_(i): actual-measurement dose-calibration factor (factor for    calibration of dose), interpolation value (interpolation value or-   α_(i): estimation value (factor for calibration of dose)).

1-9. (canceled)
 10. A particle therapy device in which an irradiationtarget is partitioned into a plurality of layers in order of depth froma body surface, and irradiation is performed while an irradiation doseis controlled for each of the layers, comprising: an irradiationapparatus that radiates a particle beam supplied from an accelerator,after forming the beam for said each of the layers; a dose monitor thatis placed in the irradiation apparatus and measures a dose in real time;a dose evaluation unit that evaluates the irradiation dose for said eachof the layers on the basis of a dose that is calculated using ameasurement value measured by the dose monitor and using a dosecalibration factor set for said each of the layers, and a dosedetermined by a treatment plan; an irradiation control device thatcontrols a irradiation amount to said each of the layers on the basis ofan evaluation result of the dose evaluation unit; and an interpolationvalue generation unit that uses actual-measurement dose-calibrationfactors each obtained by radiating a particle beam to a simulatedphantom provided with a calibration dosimeter, to thereby generate aninterpolation value or an estimation value of the dose calibrationfactor for at least one of the layers for which the actual-measurementdose-calibration factor is not obtained; wherein, for each layer subjectto the interpolation value or the calibration value, based on anirradiation condition of that layer, the interpolation-value generationunit performs weighting on each of the actual- measurementdose-calibration factors.
 11. The particle therapy device according toclaim 10, wherein, when generating the interpolation value or thecalibration value for the layer whose depth is deeper than apredetermined value, the interpolation value generation unit performssaid weighting so that a weight of the actual-measurementdose-calibration factor at a deep layer among the actual-measurementdose-calibration factors is larger than a weight of theactual-measurement dose-calibration factor at a shallow layer thereamong.
 12. The particle therapy device according to claim 10, wherein: arange shifter for adjusting energy of the particle beam is provided inthe irradiation apparatus, and the interpolation value generation unitperforms said weighting on the basis of at least one condition fromamong the energy of the particle beam emitted from the accelerator, athickness of the range shifter and a material thereof.
 13. The particletherapy device according to claim 11, wherein: a range shifter foradjusting energy of the particle beam is provided in the irradiationapparatus, and the interpolation value generation unit performs saidweighting on the basis of at least one condition from among the energyof the particle beam emitted from the accelerator, a thickness of therange shifter and a material thereof.
 14. The particle therapy deviceaccording to claim 10, wherein: a wobbler electromagnet for enlarging adiameter of an irradiation field of the particle beam is provided in theirradiation apparatus, and the interpolation-value generation unitperforms said weighting on the basis of the enlarged diameter.
 15. Theparticle therapy device according to claim 11, wherein: a wobblerelectromagnet for enlarging a diameter of an irradiation field of theparticle beam is provided in the irradiation apparatus, and theinterpolation-value generation unit performs said weighting on the basisof the enlarged diameter.
 16. The particle therapy device according toclaim 12, wherein: a wobbler electromagnet for enlarging a diameter ofan irradiation field of the particle beam is provided in the irradiationapparatus, and the interpolation-value generation unit performs saidweighting on the basis of the enlarged diameter.
 17. The particletherapy device according to claim 13, wherein: a wobbler electromagnetfor enlarging a diameter of an irradiation field of the particle beam isprovided in the irradiation apparatus, and the interpolation-valuegeneration unit performs said weighting on the basis of the enlargeddiameter.
 18. A method for setting a dose calibration factor that isused in a particle beam therapy in which an irradiation target ispartitioned into a plurality of layers in order of depth from a bodysurface and irradiation is performed while an irradiation dose iscontrolled for each of the layers, and that is for calculating a dose inthe irradiation target using a measurement value of a dose monitorplaced in an irradiation apparatus; said method comprising: a step ofradiating a particle beam to a simulated phantom provided with acalibration dosimeter to thereby obtain actual-measurementdose-calibration factors each using a depth of the calibration dosimeterin the simulated phantom as a parameter, on the basis of the measurementvalue of the dose monitor and a measurement value of the calibrationdosimeter; and an interpolation value generation step of establishing amathematical function of the dose calibration factor having the depth asa variable, on the basis of the actual-measurement dose-calibrationfactors, to thereby generate an interpolation value or an estimationvalue of the dose calibration factor corresponding to a layer for whichthe actual-measurement dose-calibration factor is not obtained; wherein,in the interpolation value generation step, for the layer subject to theinterpolation value or the calibration value, based on an irradiationcondition corresponding to that layer, weighting is performed on each ofthe actual-measurement dose-calibration factors.
 19. The method forsetting a dose calibration factor according to claim 18, wherein, in theinterpolation value generation step, at the time of generating theinterpolation value or the calibration value for the layer whose depthis deeper than a predetermined value, said weighting is performed sothat a weight of the actual-measurement dose- calibration factor at adeep depth of the calibration dosimeter among the actual-measurementdose calibration factors, is larger than a weight of theactual-measurement dose-calibration factor at a shallow depth thereof.20. The method for setting a dose calibration factor according to claim18, wherein: in the particle beam therapy, energy of the particle beamis adjusted using a range shifter; and in the interpolation valuegeneration step, said weighting is performed on the basis of at leastone condition from among the energy of the particle beam emitted from anaccelerator, a thickness of the range shifter and a material thereof.21. The method for setting a dose calibration factor according to claim19, wherein: in the particle beam therapy, energy of the particle beamis adjusted using a range shifter; and in the interpolation valuegeneration step, said weighting is performed on the basis of at leastone condition from among the energy of the particle beam emitted from anaccelerator, a thickness of the range shifter and a material thereof.22. The method for setting a dose calibration factor according to claim18, wherein: in the particle beam therapy, a diameter of an irradiationfield of the particle beam is enlarged by a wobbler electromagnet; andin the interpolation value generation step, said weighting is performedon the basis of the enlarged diameter.
 23. The method for setting a dosecalibration factor according to claim 19, wherein: in the particle beamtherapy, a diameter of an irradiation field of the particle beam isenlarged by a wobbler electromagnet; and in the interpolation valuegeneration step, said weighting is performed on the basis of theenlarged diameter.
 24. The method for setting a dose calibration factoraccording to claim 20, wherein: in the particle beam therapy, a diameterof an irradiation field of the particle beam is enlarged by a wobblerelectromagnet; and in the interpolation value generation step, saidweighting is performed on the basis of the enlarged diameter.
 25. Themethod for setting a dose calibration factor according to claim 21,wherein: in the particle beam therapy, a diameter of an irradiationfield of the particle beam is enlarged by a wobbler electromagnet; andin the interpolation value generation step, said weighting is performedon the basis of the enlarged diameter.
 26. The method for setting a dosecalibration factor according to claim 18, wherein, in the interpolationvalue generation step, said weighting is performed on the basis of theirradiation condition corresponding to said that layer, using a valuemultiplied by a unit coefficient that has been determined for every setof plural conditions constituting the irradiation condition.
 27. Themethod for setting a dose calibration factor according to claim 19,wherein, in the interpolation value generation step, said weighting isperformed on the basis of the irradiation condition corresponding tosaid that layer, using a value multiplied by a unit coefficient that hasbeen determined for every set of plural conditions constituting theirradiation condition.
 28. The method for setting a dose calibrationfactor according to claim 20, wherein, in the interpolation valuegeneration step, said weighting is performed on the basis of theirradiation condition corresponding to said that layer, using a valuemultiplied by a unit coefficient that has been determined for every setof plural conditions constituting the irradiation condition.
 29. Themethod for setting a dose calibration factor according to claim 21,wherein, in the interpolation value generation step, said weighting isperformed on the basis of the irradiation condition corresponding tosaid that layer, using a value multiplied by a unit coefficient that hasbeen determined for every set of plural conditions constituting theirradiation condition.